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Clinical Research

Advancing Heart Valve Research

At the Marcus Heart Valve Center, we actively engage in heart valve research. This allows us to offer customized diagnostic and therapeutic options for patients that may otherwise not be accessible.

Our leading-edge cardiac research program is focused on evaluating new treatments and technologies, particularly percutaneous (non-surgical/minimally invasive) treatment options for all heart valves. 


Currently Enrolling Research Trials



Transcatheter Replacement of Stenotic Aortic Valve through Implantation of ACURATE in Subjects Indicated for TAVR.
A Feasibility Study to Assess Safety and Effectiveness of the Transfemoral JenaValve Pericardial TAVR System in the Treatment of Patients with Symptomatic Severe Aortic Regurgitation.
A prospective, randomized, active (warfarin) controlled, parallel-arm clinical trial to determine if patients with an On-X aortic valve can be maintained safely and effectively on the factor Xa inhibitor apixaban.
Stroke Protection with Sentinel During Transcatheter Aortic Valve Replacement.



Transcatheter Mitral Valve Replacement with the Medtronic Intrepid™ TMVR System in patients with severe symptomatic mitral regurgitation – APOLLO Trial.
Edwards PASCAL Transcatheter Valve Repair System Pivotal Clinical Trial (CLASP IID/IIF): A prospective, multicenter, randomized, controlled pivotal trial to evaluate the safety and effectiveness of transcatheter mitral valve repair with the Edwards PASCA.
Half Moon
Evaluation of the Safety and Performance of the Half Moon Transcatheter Mitral Valve Repair (TMVr) System in High Risk Patients with Severe Symptomatic Mitral Regurgitation.
HighLife EFS
An Early Feasibility Study of the HighLife 28mm Trans-Septal Transcatheter Mitral Valve Replacement System.
Intrepid TMVR EFS
Evaluation of the Safety and Performance of The Medtronic Intrepid™ Transcatheter Mitral Valve Replacement System with Transfemoral Transseptal access in Patients with Severe, Symptomatic Mitral Regurgitation.
Percutaneous MitraClip™ Device or Surgical Mitral Valve Repair in Patients with Primary Mitral Regurgitation who are Candidates for Surgery.
A prospective, multi-center trial to evaluate the safety and effectiveness of beating heart mitral valve repair with the HARPOON™ System.
Clinical Trial to Evaluate the Safety and Effectiveness of Using the Tendyne Mitral Valve System for the Treatment of Symptomatic Mitral Regurgitation.



Clinical Trial to Evaluate Cardiovascular Outcomes in Patients Treated with the Tricuspid Valve Repair System Pivotal (TRILUMINATE Pivotal).
Edwards EVOQUE Tricuspid Valve Replacement System: Investigation of Safety and Clinical Efficacy using a Novel Device.


For full details visit the Clinical Trials Database.

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